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Piroctone Olamine vs zinc pyrithione in shampoo

Updated: May 6, 2023

Dandruff is caused by the stratum corneum constantly peeled off and it's a result of metabolism.

When there is too much dandruff and the pores are blocked, it is easy to cause the hair loss and bacteria proliferation. The type of dandruff will change to pathological dandruff.

A large number of studies have shown that the mechanism and severity of dandruff are closely related to the abnormal reproduction of Malassezia.

Malassezia is a yeast class single-celled fungus, which survives by consuming fatty acids in sebum. The Malassezia causes excessive proliferation of the stratum corneum, which promotes t

the continuous abnormal shedding of stratum corneum cells in the form of scales. This shedding of scales is called dandruff.

Piroctone Olamine is well-known for its antibacterial effect and is often used in shampoos to replace ZPT( zinc pyrithione). It has been used in personal care products for more than 30 years. It is also used as a preservative and thickener. Compared with other anti-dandruff agents, Piroctone Olamine has lower toxicity, excellent solubility, and compounding properties. It will not cause precipitation or delamination when mixed with other cosmetic raw materials. It has low irritation and will not cause hair loss. hair breaks, so it is widely used in anti-dandruff shampoo products.

In a controlled clinical trial, the results showed that Piroctone Olamine is superior to ketoconazole and zinc pyrithione, and Piroctone Olamine can reduce oil secretion.

Piroctone Olamine is the only anti-dandruff and antipruritic agent in the world that can be used as a Wash-Free product. It is through the methods of sterilization, antibacterial, anti-oxidation, and decomposition of oxides to fundamentally block the external factors caused by dandruff, effectively eradicate dandruff, and stop itching.

1.Anti-dandruff effect of piroctone olamine

Some of the common anti-dandruff agents currently on the market have a strong degreasing effect. Long-term use of such anti-dandruff agents will cause the atrophy of the sebaceous glands which will not only accelerate the aging of epidermal cells and increase dandruff but also cause dry listless hair, even brittle hair. Piroctone Olamine has no degreasing effect. It will eliminate dandruff and relieve itching without damaging the hair. The mechanism of Piroctone Olamine is can effectively inhibit bacteria, decompose peroxide, and reduce the irritation caused by peroxide.

Instead of temporarily eliminating dandruff from the surface by degreasing. Piroctone Olamine has good antioxidant properties and can fundamentally eradicate dandruff and itching, This is also one of the reasons why piroctone olamine performance is better than other similar products.

Shampoo with 0.75% piroctone olamine and placebo shampoo. Measure the anti-dandruff effect (use it once per week), and the results are shown in the chart.

From the data in the chart, it can be seen that compared with the blank sample, piroctone olamine can significantly reduce the amount of dandruff, and with the extension of time, the anti-dandruff effect is further improved.

2 Irritation

Piroctone olamine can be quickly degraded after being absorbed by the skin, it won't accumulate and has no side effects on the skin. At the same time, the irritation of piroctone olamine is very small, study shows irritation to the skin is not significantly increased compared with the placebo shampoo. Moreover, piroctone olamine can quickly combine with the iron ions in the water to lose its original toxicity, and cause less harm to aquatic organisms.

3.Piroctone olamine toxicity

People in the world attach great importance to the safety of anti-dandruff agents.

Piroctone olamine has the lowest toxicity index among similar anti-dandruff agents.

It's the only agent that could be used in leave-on products such as hair cream, hair spray, mousse, and hair dye.

International regulations on the usage of Piroctone olamine

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